| 產(chǎn)品編號(hào) | bsm-63310R |
| 英文名稱 | phospho-Nucleophosmin (T199) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化核仁磷酸蛋白重組兔單抗 |
| 別 名 | NO38; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleophosmin; nucleophosmin nucleoplasmin family member 1; Numatrin. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 5D10 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,Flow-Cyt=1:20-1:100,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 33 kDa |
| 檢測(cè)分子量 | 33 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Nucleophosmin around the phosphorylation site of T199: RD-pT-PA |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. SWISS: P06748 Gene ID: 4869 ????核仁磷酸蛋白（nucleophosmin）是雌激素調(diào)控的一種核仁蛋白， Nucleophosmin(又稱為NPM、B23、Numatrin、NO38)位于核仁的顆粒區(qū),與其他一些核蛋白如C23、P120等可相互作用。 ????NPM可以在細(xì)胞核與細(xì)胞漿之間穿梭,其定位受細(xì)胞周期及一些細(xì)胞毒藥物的影響。NPM基因在多種人類腫瘤中過(guò)表達(dá),因此被公認(rèn)為腫瘤標(biāo)志物和癌基因.后來(lái)研究發(fā)現(xiàn)NPM也具有抑制腫瘤的功能,它的缺失、突變甚至重排與多種腫瘤的發(fā)生密切相關(guān). |
