| 產(chǎn)品編號 | bsm-63292R |
| 英文名稱 | phospho-MET (Y1349) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化肝細(xì)胞生長因子受體(原癌基因)重組兔單抗 |
| 別 名 | AUTS9; D249; HGF; HGF receptor; HGFR; MET; Par4; RCCP2. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 5F15 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:100-1:200,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 156 kDa |
| 檢測分子量 | 156 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human c Met around the phosphorylation site of Y1349: GEH-pY-VHV |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. SWISS: P08581 Gene ID: 4233 細(xì)胞膜受體（Membrane Receptors) c-Met蛋白是肝細(xì)胞生長因子受體（Hepatocyte growth factor receptor, HGFR），又稱受體蛋白酪氨酸激酶，肝細(xì)胞生長因子和過度表達的c-Met(HGFR)蛋白結(jié)合，在腫瘤的發(fā)生、進展和血管形成中都起著重要作用。 c-met蛋白也是HGF特異性受體，具有內(nèi)源性酪氨酸激酶的活性，HGF與c-met蛋白特異性結(jié)合對腫瘤細(xì)胞生長、分化及惡性轉(zhuǎn)化可能具有重要的關(guān)聯(lián)。 |
